Syncaine® (tricaine methanesulfonate, also known as MS-222 or TMS) is Syndel’s flagship fish anesthetic for the temporary immobilization of fish, amphibians, and other aquatic cold-blooded animals (poikilotherms).
For decades, Syncaine® has been used by aquaculture professionals, researchers, veterinarians, and aquatic animal care professionals to support the safe and controlled handling of aquatic animals during procedures such as spawning and fish stripping, weighing, measuring, marking, surgery, photography, transport, and research.
Syncaine® is manufactured in North America at Syndel’s FDA-inspected facility in Ferndale, Washington, in accordance with Good Manufacturing Practices (GMP). These standards help ensure the product’s consistent purity, strength, and quality.
Syncaine® is approved in multiple countries, including the United States, Canada, Norway, Chile, and the United Kingdom. Product approvals, applications, and requirements vary by country and region.
Available Sizes
- 10 g bottle
- 100 g bottle
- 1 kg bottle
Related Products
For fish transport and handling, explore Vidalife.
For spawning applications, explore Syndel’s spawning aids.
For additional information about fish anesthetics, visit our Fish Anesthetics FAQ.
Safety & Handling
Always review the current product label, directions for use, and safety information before using Syncaine®.
Syncaine® must be used in accordance with applicable regulatory requirements and approved directions for use. Do not overexpose fish to lethal concentrations. Anesthetized fish should be returned to fresh water before excessive exposure occurs. Additional exposure following medullary collapse may result in mortality.
Use in food fish, permitted species, water temperatures, and withdrawal periods are subject to jurisdiction-specific requirements. Refer to the current approved label and directions for use applicable to your location before treatment.
Store at room temperature in a well-ventilated, secure area with the container tightly closed. Wear appropriate personal protective equipment when handling the product. In the event of exposure, flush the affected area with clean water and seek appropriate medical advice.
When preparing an anesthetic bath, use appropriate water and avoid distilled or deionized water or water containing chlorine, heavy metals, or other toxic contaminants.
Always validate the planned concentration and handling procedure before large-scale use. Refer to the current Syncaine® Directions for Use for approved application information and handling recommendations.
Dispose of product and prepared solutions in accordance with applicable local, state/provincial, and federal regulations.
Withdrawal Periods
Withdrawal periods and other requirements vary by jurisdiction, species, intended use, and water temperature. Always consult the current approved label and directions for use applicable to your country or region before treating fish intended for human consumption.
Consult your veterinarian or qualified fish health professional for additional guidance.
